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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract:

Gene therapy provides a potential cure for hemophilia B, and significant progress has been achievedin liver-directed gene transfer mediated by adeno-associated viral vectors.vectors and hFIX expression cassette may positively contribute to the ultimate success of hemophilia B geneIn addition, the regulatory elements that control the FIX gene expression in these cassettesreconstructs of hFIX with AAV vector may potentially contribute to the creation of an efficacious gene

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 141-147 doi: 10.1007/s11684-009-0041-6

Abstract: To explore the possibility of Rab9-related gene therapy for neurodegenerative diseases, we packed LentivirusWestern blotting revealed that the Rab9 gene expression in BALB/c mice brain was up-regulated significantlyLentivirus encoding Rab9 can increase the expression of Rab9 gene effectively, which might offer a novel

Keywords： Rab9     lentivirus     gene therapy     gene transfer    

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Bacteriophages in water pollution control: Advantages and limitations

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1378-y

Abstract:

•Phages can be better indicators of enteric viruses than fecal indicator bacteria.

Keywords： Phage     Water pollution monitoring     Harmful bacteria biocontrol     Horizontal gene transfer     Bacterial resistance    

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Assessment of antibiotic resistance genes in dialysis water treatment processes

Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1136-1

Abstract:

• Quantitative global ARGs profile in dialysis water was investigated.

• Totally 35 ARGs were found in the dialysis treatment train.

• 29 ARGs (highest) were found in carbon filtration effluent.

• erm and mtrD-02 occurred in the final effluent.

• The effluent was associated with health risks even after RO treatment.

Keywords： Dialysis water     Treatment process     Antibiotic resistance gene     High-throughput quantitative PCR     Horizontalgene transfer    

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Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions

Xiaoming HU,Jing GUO,Chunling BAI,Zhuying WEI,Li GAO,Tingmao HU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 87-96 doi: 10.15302/J-FASE-2016087

Abstract: In the present study, follistatin ( ) gene expression vectors with either a bicistronic gene transfercassette alone, or a bicistron gene cassette carrying a matrix attachment region (MAR) were constructedpMAR-FST vector, which excluded the resistant genes and frame structure, enhances and stabilizes gene

Keywords： safety of transgenic     bicistron gene transfer body     transgenic mice     muscle development    

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Recent progress in hydrodynamic characteristics research and application of annular centrifugal extractors

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 854-873 doi: 10.1007/s11705-022-2156-0

Abstract: used in many industrial fields because of its low residence time, compact structure, and high mass transferMore recently, research on hydrodynamic behavior and structural optimization has received widespreadHence, this paper reviews research progress regarding ACE in terms of hydrodynamic characteristics and

Keywords： annular centrifugal extractor     hydrodynamic characteristics     structure optimization     the latest application    

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Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: Polymer-based conjugates are an interesting option and challenge for the design of nano-sized drug-delivery systems, as they require advanced conjugation chemistry and precise engineering. In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the delivery process, namely 1) protection of the cargo from extracellular degradation, 2) avoidance of non-specific interactions with non-targeted tissues, 3) efficient entry into the target cells, 4) intracellular trafficking to the site of action and 5) cargo release. To take on these obstacles, multifunctional conjugates can act as “smart polymers” with microenvironment-sensing dynamics to facilitate the separate delivery steps. Synthesis of defined polymer architectures with precise functionalization enables structure-activity relationships to be investigated and the integration of key functions for efficient delivery. Thus bioresponsive polymer conjugates, which are equipped with molecular devices responding to the certain microenvironments within the delivery pathway (e.g. pH, redox potential, enzymes) can be assembled. This review focuses on the modular engineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleic acid carriers.

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

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Identification of pollution sources in rivers using a hydrodynamic diffusion wave model and improved

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1685-1

Abstract:

● A hydrodynamic-Bayesian inference model was developed for water

Keywords： Identification of pollution sources     Water quality restoration     Bayesian inference     Hydrodynamic model    

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Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)

ZHAI Wenjie, LIU Changxiong, LIANG Yingchun

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 4,   Pages 441-448 doi: 10.1007/s11465-008-0074-6

Abstract: mechanisms of CTMP and determine the optimum process variables in a CTMP process, a three-dimensional hydrodynamic

Keywords： numerical analysis     practical CTMP     circular-translational-moving polishing     CTMP     different    

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Uncertainty quantification of stability and damage detection parameters of coupled hydrodynamic-ground

Nazim Abdul NARIMAN, Tom LAHMER, Peyman KARAMPOUR

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 2,   Pages 303-323 doi: 10.1007/s11709-018-0462-x

Abstract: In this paper, models of the global system of the Koyna dam have been created using ABAQUS software considering the dam-reservoir-foundation interaction. Non coupled models and the coupled models were compared regarding the horizontal displacement of the dam crest and the differential settlement of the dam base in clay foundation. Meta models were constructed and uncertainty quantification process was adopted by the support of Sobol’s sensitivity indices considering five uncertain parameters by exploiting Box-Behnken experimental method. The non coupled models results determined overestimated predicted stability and damage detection in the dam. The rational effects of the reservoir height were very sensitive in the variation of the horizontal displacement of the dam crest with a small interaction effect with the beta viscous damping coefficient of the clay foundation. The modulus of elasticity of the clay foundation was the decisive parameter regarding the variation of the differential settlement of the dam base. The XFEM approach has been used for damage detection in relation with both minimum and maximum values of each uncertain parameter. Finally the effects of clay and rock foundations were determined regarding the resistance against the propagation of cracks in the dam, where the rock foundation was the best.

Keywords： massed foundation     hydrodynamic pressure     Box-Behnken method     meta model     Sobol’s sensitivity indices    

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Scenario analysis of water pollution control in the typical peri-urban river using a coupled hydrodynamic-water

Haifeng JIA, Shuo WANG, Mingjie WEI, Yansong ZHANG

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 2,   Pages 255-265 doi: 10.1007/s11783-010-0279-x

Abstract: The water quality pollution and ecological deterioration in peri-urban rivers are usually serious under rapid urbanization and economic growth. In the study, a typical peri-urban river, Nansha River, was selected as a case study to discuss the scheme of peri-urban river rehabilitation. Located in the north part of the Beijing central region, the Nansha River watershed has been designated as an ecologically friendly garden-style area with high-tech industry parks and upscale residential zones. However, the Nansha River is currently seriously contaminated by urban and rural pollutants from both nonpoint sources (NPS) and point sources (PS). In this study, the pollutant loads from point sources and nonpoint sources in the Nansha River watershed were first assessed. A coupled model, derived from the Environmental Fluid Dynamics Code and Water Quality Analysis Simulation Program, was developed to simulate the hydrodynamics and water quality in the Nansha River. According to the characteristics of the typical peri-urban river, three different PS and NPS control scenarios were designed and examined by modeling analyses. Based on the results of the scenario analysis, a river rehabilitation scheme was recommended for implementation.

Keywords： peri-urban river     coupled hydrodynamic-water quality modeling     scenario analysis     river rehabilitation    

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Development of a hydrodynamic model and the corresponding virtual software for dual-loop circulating

Shanwei Hu, Xinhua Liu

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 579-590 doi: 10.1007/s11705-020-1953-6

Abstract: fluidized bed (CFB) reactors have been widely applied in industry because of their good heat and mass transfermodeling scheme was implemented by using the EMMS model and/or its extension models to compute the hydrodynamic

Keywords： multi-loop circulating fluidized bed     mathematical modeling     energy minimization multiscale     virtual fluidization     mesoscale structure    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 86-93 doi: 10.1007/s11684-011-0118-x

Abstract: Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 genetransfer might present a valuable approach to treat brain ischemic disorders.

Keywords： adeno-associated virus     angiogenesis     gene transfer     ischemia     middle cerebral artery occlusion     netrin-1    

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Recent Developments in Hydrodynamic Cavitation Reactors: Cavitation Mechanism, Reactor Design, and Applications Review

Haoxuan Zheng, Ying Zheng, Jesse Zhu

Engineering 2022, Volume 19, Issue 12,   Pages 180-198 doi: 10.1016/j.eng.2022.04.027

Abstract:

Hydrodynamic cavitation is considered to be a promising technology for process intensification, dueIn the past decade, advancements have been made in the fundamental understanding of hydrodynamic cavitationTwo types of hydrodynamic cavitation reactors—namely, stationary and rotational—are comparedThe design parameters of a hydrodynamic cavitation reactor and reactor performance at the laboratoryThe unique features of hydrodynamic cavitation have been widely applied to various chemical reactions

Keywords： Hydrodynamic cavitation     Cavitation nuclei     Hydroxyl radicals     Stationary/rotational hydrodynamic cavitation    

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Title Author Date Type Operation

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Journal Article

Bacteriophages in water pollution control: Advantages and limitations

Journal Article

Assessment of antibiotic resistance genes in dialysis water treatment processes

Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng

Journal Article

Matrix attachment regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions

Xiaoming HU,Jing GUO,Chunling BAI,Zhuying WEI,Li GAO,Tingmao HU,Shorgan BOU,Guangpeng LI

Journal Article

Recent progress in hydrodynamic characteristics research and application of annular centrifugal extractors

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article

Identification of pollution sources in rivers using a hydrodynamic diffusion wave model and improved

Journal Article

Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)

ZHAI Wenjie, LIU Changxiong, LIANG Yingchun

Journal Article

Uncertainty quantification of stability and damage detection parameters of coupled hydrodynamic-ground

Nazim Abdul NARIMAN, Tom LAHMER, Peyman KARAMPOUR

Journal Article

Scenario analysis of water pollution control in the typical peri-urban river using a coupled hydrodynamic-water

Haifeng JIA, Shuo WANG, Mingjie WEI, Yansong ZHANG

Journal Article

Development of a hydrodynamic model and the corresponding virtual software for dual-loop circulating

Shanwei Hu, Xinhua Liu

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion

Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG

Journal Article

Recent Developments in Hydrodynamic Cavitation Reactors: Cavitation Mechanism, Reactor Design, and Applications

Haoxuan Zheng, Ying Zheng, Jesse Zhu

Journal Article